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Issue 18, 2010
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Efforts toward elucidating Thalidomide’s molecular target: an expedient synthesis of the first Thalidomide biotin analogue

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Abstract

Herein we describe the synthesis of the first Thalidomidebiotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1,3-dipolar cycloaddition or “click” synthetic methodology.

Graphical abstract: Efforts toward elucidating Thalidomide’s molecular target: an expedient synthesis of the first Thalidomide biotin analogue

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Publication details

The article was received on 29 Apr 2010, accepted on 25 Jun 2010 and first published on 13 Jul 2010


Article type: Communication
DOI: 10.1039/C0OB00060D
Citation: Org. Biomol. Chem., 2010,8, 4059-4062
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    Efforts toward elucidating Thalidomide’s molecular target: an expedient synthesis of the first Thalidomide biotin analogue

    S. G. Stewart, C. J. Braun, M. E. Polomska, M. Karimi, L. J. Abraham and K. A. Stubbs, Org. Biomol. Chem., 2010, 8, 4059
    DOI: 10.1039/C0OB00060D

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