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Issue 18, 2010
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Efforts toward elucidating Thalidomide’s molecular target: an expedient synthesis of the first Thalidomide biotin analogue

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Abstract

Herein we describe the synthesis of the first Thalidomidebiotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1,3-dipolar cycloaddition or “click” synthetic methodology.

Graphical abstract: Efforts toward elucidating Thalidomide’s molecular target: an expedient synthesis of the first Thalidomide biotin analogue

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Article information


Submitted
29 Apr 2010
Accepted
25 Jun 2010
First published
13 Jul 2010

Org. Biomol. Chem., 2010,8, 4059-4062
Article type
Communication

Efforts toward elucidating Thalidomide’s molecular target: an expedient synthesis of the first Thalidomide biotin analogue

S. G. Stewart, C. J. Braun, M. E. Polomska, M. Karimi, L. J. Abraham and K. A. Stubbs, Org. Biomol. Chem., 2010, 8, 4059
DOI: 10.1039/C0OB00060D

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