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Issue 16, 2010
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Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate

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Abstract

The triplet aryl cation photochemically generated from fluoroquinolones bearing a fluoro atom at position 8 attacks guanosine monophosphate (kr > 109 M−1s−1) and forms covalent adducts. The reaction is a model for the implementation of oxygen-independent photochemotherapy

Graphical abstract: Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate

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Supplementary files

Article information


Submitted
28 Apr 2010
Accepted
09 Jun 2010
First published
23 Jun 2010

Org. Biomol. Chem., 2010,8, 3621-3623
Article type
Communication

Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate

E. Fasani, I. Manet, M. L. Capobianco, S. Monti, L. Pretali and A. Albini, Org. Biomol. Chem., 2010, 8, 3621
DOI: 10.1039/C0OB00056F

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