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Issue 14, 2010
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Supramolecular hydrogels inspired by collagen for tissue engineering

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Abstract

Supramolecular hydrogels are promising biomaterials for cell culture in 2-D and 3-D environments. Inspired by the chemical structure of collagen, which bears the repeating tripeptide of glycine-Xaa-4R-hydroxyproline (GXO; Xaa is any one of the natural amino acids), we designed and synthesized a small library of supramolecular hydrogelators (a total of 6). We found that four of the hydrogels were suitable for NIH 3T3 cell culture in the 2-D environments. Gel 2, the best hydrogel, has properties that are similar to those of collagen for 3T3 cell culture. These findings not only provide more supramolecular hydrogel candidates for tissue engineering, but also offer a new strategy for designing biomaterials that mimic nature.

Graphical abstract: Supramolecular hydrogels inspired by collagen for tissue engineering

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Supplementary files

Article information


Submitted
10 Feb 2010
Accepted
10 May 2010
First published
26 May 2010

Org. Biomol. Chem., 2010,8, 3267-3271
Article type
Paper

Supramolecular hydrogels inspired by collagen for tissue engineering

Y. Hu, H. Wang, J. Wang, S. Wang, W. Liao, Y. Yang, Y. Zhang, D. Kong and Z. Yang, Org. Biomol. Chem., 2010, 8, 3267
DOI: 10.1039/C002609C

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