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Issue 12, 2010
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Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

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Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

Graphical abstract: Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

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Article information


Submitted
26 Jan 2010
Accepted
25 Mar 2010
First published
28 Apr 2010

Org. Biomol. Chem., 2010,8, 2777-2783
Article type
Paper

Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

A. R. Burns, J. H. Kerr, W. J. Kerr, J. Passmore, L. C. Paterson and A. J. B. Watson, Org. Biomol. Chem., 2010, 8, 2777
DOI: 10.1039/C001772H

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