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Issue 9, 2010
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Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds

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Abstract

In the present work, we have developed a highly efficient temperature-dependent chemo-enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri-glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert-butoxycarbonyl)acetate (Boc-gly-Ph-pNO2) (2) as the acylating agent. This methodology offers efficient and controlled loading of amino acid (glycine) on polyhydroxy compounds.

Graphical abstract: Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds

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Publication details

The article was received on 23 Dec 2009, accepted on 19 Feb 2010 and first published on 11 Mar 2010


Article type: Paper
DOI: 10.1039/B927021C
Org. Biomol. Chem., 2010,8, 2228-2237

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    Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds

    S. Malhotra, M. Calderón, A. K. Prasad, V. S. Parmar and R. Haag, Org. Biomol. Chem., 2010, 8, 2228
    DOI: 10.1039/B927021C

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