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Issue 8, 2010
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The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

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Abstract

In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particular automated continuous flow methods have greatly assisted in the optimisation of reaction conditions and facilitated scale up operations involving hazardous chemical materials. Overall a collection of twenty diverse analogues of a casein kinase I inhibitor has been synthesised by changing three principle binding vectors.

Graphical abstract: The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

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Publication details

The article was received on 02 Dec 2009, accepted on 18 Jan 2010 and first published on 17 Feb 2010


Article type: Paper
DOI: 10.1039/B925327K
Org. Biomol. Chem., 2010,8, 1798-1806

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    The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

    F. Venturoni, N. Nikbin, S. V. Ley and I. R. Baxendale, Org. Biomol. Chem., 2010, 8, 1798
    DOI: 10.1039/B925327K

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