Jump to main content
Jump to site search

Issue 9, 2010
Previous Article Next Article

Towards click bioconjugations on cube-octameric silsesquioxane scaffolds

Author affiliations

Abstract

Cube-octameric silsesquioxane (POSS) based conjugation scaffolds for copper catalysed azide-alkyne [3+2] cycloaddition are reported. The synthetic route to octaazido and octaalkyno functionalised POSS templates without cage rearrangements is described. A set of click couplings is conducted including the first effective conjugation with a fully unprotected functional peptide towards a POSS assembled peptide octamer.

Graphical abstract: Towards click bioconjugations on cube-octameric silsesquioxane scaffolds

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Nov 2009, accepted on 18 Feb 2010 and first published on 12 Mar 2010


Article type: Paper
DOI: 10.1039/B923393H
Org. Biomol. Chem., 2010,8, 2212-2218

  •   Request permissions

    Towards click bioconjugations on cube-octameric silsesquioxane scaffolds

    S. Fabritz, D. Heyl, V. Bagutski, M. Empting, E. Rikowski, H. Frauendorf, I. Balog, W. Fessner, Jörg. J. Schneider, O. Avrutina and H. Kolmar, Org. Biomol. Chem., 2010, 8, 2212
    DOI: 10.1039/B923393H

Search articles by author

Spotlight

Advertisements