Issue 19, 2010
From the journal:

Organic & Biomolecular Chemistry

Asymmetric trimethine 3H-indocyaninedyes: efficient synthesis and proteinlabeling†

Fengling Song,a   Li Wang,a   Xiaoqiang Qiao,b   Bingshuai Wang,a   Shiguo Sun,a   Jiangli Fan,a   Lihua Zhangb  and  Xiaojun Peng*a  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, Dalian 116012, P.R. China
E-mail: pengxj@dlut.edu.cn
Fax: +86-411-39893800
Tel: +86-411-39893899

b CAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research & Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China

Abstract

We present an efficient method to synthesize three new asymmetric trimethine cyanine dyes containing only one carboxylic acid group for bioconjugation. Two of them have better protein labeling performance than other conventional cyanine dyes due to their particular structure design.

Graphical abstract: Asymmetric trimethine 3H-indocyanine dyes: efficient synthesis and protein labeling

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Article information

DOI
https://doi.org/10.1039/C0OB00227E
Article type
Communication
Submitted
08 Jun 2010
Accepted
09 Jul 2010
First published
04 Aug 2010

Org. Biomol. Chem., 2010,8, 4249-4251

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Asymmetric trimethine 3H-indocyanine dyes: efficient synthesis and protein labeling

F. Song, L. Wang, X. Qiao, B. Wang, S. Sun, J. Fan, L. Zhang and X. Peng, Org. Biomol. Chem., 2010, 8, 4249 DOI: 10.1039/C0OB00227E

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