Issue 20, 2010

Regioselective syntheses of fully-substituted 1,2,3-triazoles: the CuAAC/C–H bond functionalization nexus

Abstract

Regioselective syntheses of 1,4,5-trisubstituted 1,2,3-triazoles were accomplished by three different strategies, relying on (i) the interception of stoichiometrically formed 5-cuprated-1,2,3-triazoles, (ii) the use of stoichiometrically functionalized alkynes or (iii) catalytic C–H bond functionalizations. This perspective article summarizes progress in this research area until June 2010.

Graphical abstract: Regioselective syntheses of fully-substituted 1,2,3-triazoles: the CuAAC/C–H bond functionalization nexus

Article information

Article type
Perspective
Submitted
04 Jun 2010
Accepted
08 Jul 2010
First published
23 Aug 2010

Org. Biomol. Chem., 2010,8, 4503-4513

Regioselective syntheses of fully-substituted 1,2,3-triazoles: the CuAAC/C–H bond functionalization nexus

L. Ackermann and H. K. Potukuchi, Org. Biomol. Chem., 2010, 8, 4503 DOI: 10.1039/C0OB00212G

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