Issue 20, 2010

A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: an expeditious protocol towards regiospecific 1-aryl benzotriazoles

Abstract

An efficient and highly versatile method for the synthesis of diverse regiospecific 1-arylbenzotriazoles being important medicinal scaffolds, by the copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes of 2-haloaryldiazonium salts in PEG-water has been developed. A very simple reaction protocol, large number of substrate affordability and excellent yields are the main features of this methodology.

Graphical abstract: A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: an expeditious protocol towards regiospecific 1-aryl benzotriazoles

Supplementary files

Article information

Article type
Paper
Submitted
27 May 2010
Accepted
14 Jul 2010
First published
31 Aug 2010

Org. Biomol. Chem., 2010,8, 4720-4729

A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: an expeditious protocol towards regiospecific 1-aryl benzotriazoles

C. Mukhopadhyay, P. K. Tapaswi and R. J. Butcher, Org. Biomol. Chem., 2010, 8, 4720 DOI: 10.1039/C0OB00177E

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