Issue 19, 2010
From the journal:

Organic & Biomolecular Chemistry

Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities†

Jiun-Jie Shie,a   Chih-An Chen,b   Chih-Chien Lin,c   Angela Fay Ku,b   Ting-Jen R. Cheng,a   Jim-Min Fang*ab  and  Chi-Huey Wong*a  

* Corresponding authors

a The Genomics Research Center, Academia Sinica, Taipei, Taiwan
E-mail: chwong@gate.sinica.edu.tw
Fax: (8862)27898771
Tel: (8862)27899400

b Department of Chemistry, National Taiwan University, Taipei, Taiwan
E-mail: jmfang@ntu.edu.tw
Fax: (8862)23637812
Tel: (8862)33661663

c Institute of Biochemistry Sciences, National Taiwan University, Taipei, Taiwan

Abstract

Three methods are utilized to synthesize a variety of 6,8-di-C-glycosylflavones bearing identical or distinct glycosyl moieties. Some C-glycosylation compounds are found to have better anti-inflammation activities than the parent flavones. Among them, 6,8-di-C-glucosylapigenin (known as vicenin-2) shows inhibition of TNF-α expression and NO production with IC50 values of 6.8 and 5.2 μM, respectively.

Graphical abstract: Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0OB00011F
Article type
Paper
Submitted
16 Apr 2010
Accepted
28 Jun 2010
First published
19 Aug 2010

Org. Biomol. Chem., 2010,8, 4451-4462

Permissions

Request permissions

Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities

J. Shie, C. Chen, C. Lin, A. F. Ku, T. R. Cheng, J. Fang and C. Wong, Org. Biomol. Chem., 2010, 8, 4451 DOI: 10.1039/C0OB00011F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements