Issue 18, 2010
From the journal:

Organic & Biomolecular Chemistry

Strain-promoted double-click reaction for chemical modification of azido-biomolecules†

Isao Kii,*a   Akira Shiraishi,a   Toshiyuki Hiramatsu,ab   Takeshi Matsushita,c   Hidehiro Uekusa,d   Suguru Yoshida,b   Makoto Yamamoto,e   Akira Kudo,a   Masatoshi Hagiwarae  and  Takamitsu Hosoya*ab  

* Corresponding authors

a Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan
E-mail: ikii@bio.titech.ac.jp

b Laboratory of Chemical Biology, Graduate School of Biomedical Science, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University and SORST, Japan Science and Technology Agency (JST), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
E-mail: thosoya.cb@tmd.ac.jp
Fax: +81-3-5280-8117

c Goi Research Center, Chisso Petrochemical Corporation, 5-1 Goikaigan, Ichihara, Chiba 290-8551, Japan

d Department of Chemistry and Materials Science, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, Japan

e Department of Functional Genomics, Medical Research Institute, Graduate School of Biomedical Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Abstract

The strain-promoted “double-click” (SPDC) reaction using Sondheimer diyne, a novel convergent method conjugating three molecules spontaneously, has enabled us to readily modify an azido-biomolecule with a small reporter azido-molecule.

Graphical abstract: Strain-promoted double-click reaction for chemical modification of azido-biomolecules

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0OB00003E
Article type
Communication
Submitted
15 Apr 2010
Accepted
08 Jul 2010
First published
26 Jul 2010

Org. Biomol. Chem., 2010,8, 4051-4055

Permissions

Request permissions

Strain-promoted double-click reaction for chemical modification of azido-biomolecules

I. Kii, A. Shiraishi, T. Hiramatsu, T. Matsushita, H. Uekusa, S. Yoshida, M. Yamamoto, A. Kudo, M. Hagiwara and T. Hosoya, Org. Biomol. Chem., 2010, 8, 4051 DOI: 10.1039/C0OB00003E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements