A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands

John E. Moses; Dougal J. Ritson; Fengzhi Zhang; Caterina Maria Lombardo; Shozeb Haider; Neil Oldham; Stephen Neidle

doi:10.1039/C005055E

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A click chemistry approach to C₃ symmetric, G-quadruplex stabilising ligands†

John E. Moses,*^a Dougal J. Ritson,^a Fengzhi Zhang,^a Caterina Maria Lombardo,^b Shozeb Haider,^b Neil Oldham^a and Stephen Neidle*^b

Author affiliations

* Corresponding authors

^a The School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: john.moses@nottingham.ac.uk
Fax: (+44) 115-951-3555
Tel: (+44) 115-951-3533

^b CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London
E-mail: stephen.neidle@pharmacy.ac.uk
Fax: (+44) 20-7753-5970
Tel: (+44) 20-7753-5969

Abstract

Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide–alkyne ‘click’ reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.

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Article information

DOI: https://doi.org/10.1039/C005055E
Article type: Communication
Submitted: 13 Apr 2010
Accepted: 12 May 2010
First published: 25 May 2010

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Org. Biomol. Chem., 2010,8, 2926-2930

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A click chemistry approach to C₃ symmetric, G-quadruplex stabilising ligands

J. E. Moses, D. J. Ritson, F. Zhang, C. M. Lombardo, S. Haider, N. Oldham and S. Neidle, Org. Biomol. Chem., 2010, 8, 2926 DOI: 10.1039/C005055E

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Organic & Biomolecular Chemistry