Issue 16, 2010
From the journal:

Organic & Biomolecular Chemistry

Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells†

Xin Li,a   Shijing Qian,b   Qiaojun He,b   Bo Yang,b   Jia Lic  and  Yongzhou Hu*a  

* Corresponding authors

a ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
E-mail: huyz@zju.edu.cn
Fax: 086-571-88208460
Tel: 086-571-88208460

b Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

c State Key Laboratory of Drug Research, Shanghai Institute of Material Medica, Chinese Academy of Science, Shanghai 201203, China

Abstract

A new fluorescent turn-on probe for the rapid optical sensing of thiols has been designed and synthesized. The probe displays high on/off signal ratios and high selectivity towards thiols. The potential of the probe as a biosensor for thiols was demonstrated by imaging of thiols in living cells.

Graphical abstract: Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells

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Article information

DOI
https://doi.org/10.1039/C004344C
Article type
Communication
Submitted
17 Mar 2010
Accepted
18 Jun 2010
First published
30 Jun 2010

Org. Biomol. Chem., 2010,8, 3627-3630

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Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells

X. Li, S. Qian, Q. He, B. Yang, J. Li and Y. Hu, Org. Biomol. Chem., 2010, 8, 3627 DOI: 10.1039/C004344C

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