Issue 17, 2010

Unexpected iron(iii) chloride-catalysed dimerisation of 1,1,3-trisubstituted-prop-2-yn-1-ols as an expedient route to highly conjugated indenes

Abstract

A method to prepare highly conjugated indenes efficiently by iron(III) chloride-catalysed dimerisation of trisubstituted propargylic alcohols under very mild conditions at room temperature is described. The reactions are rapid and operationally straightforward, giving the indene products in good yields and regioselectivity.

Graphical abstract: Unexpected iron(iii) chloride-catalysed dimerisation of 1,1,3-trisubstituted-prop-2-yn-1-ols as an expedient route to highly conjugated indenes

Supplementary files

Article information

Article type
Paper
Submitted
25 Feb 2010
Accepted
08 Jun 2010
First published
20 Jul 2010

Org. Biomol. Chem., 2010,8, 4016-4025

Unexpected iron(III) chloride-catalysed dimerisation of 1,1,3-trisubstituted-prop-2-yn-1-ols as an expedient route to highly conjugated indenes

W. Rao and P. W. H. Chan, Org. Biomol. Chem., 2010, 8, 4016 DOI: 10.1039/C003522J

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