Issue 13, 2010

Gold-catalysed room-temperature cycloisomerisation of alkynes and unactivated enolisable ketones

Abstract

The cycloisomerisation of simple keto-alkynes proceeds at room temperature under the mild conditions of gold catalysis. Bicyclic fused and spiro compounds can be obtained by overall 5-exo and 6-exo carbon–carbon bond-forming cyclisations.

Graphical abstract: Gold-catalysed room-temperature cycloisomerisation of alkynes and unactivated enolisable ketones

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2010
Accepted
12 May 2010
First published
25 May 2010

Org. Biomol. Chem., 2010,8, 2918-2922

Gold-catalysed room-temperature cycloisomerisation of alkynes and unactivated enolisable ketones

P. W. Davies and C. Detty-Mambo, Org. Biomol. Chem., 2010, 8, 2918 DOI: 10.1039/C003473H

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