Issue 19, 2010

Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of α-aminophosphonic acid derivatives

Abstract

Efficient synthesis of α-aminophosphonic acid derivatives is achieved, the key step being a diastereoselective hydrophosphonylation of N-diphenylphosphinyl imines using a readily available chiral cyclic (R,R)-TADDOL-phosphite derived from inexpensive natural tartaric acid.

Graphical abstract: Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of α-aminophosphonic acid derivatives

Supplementary files

Article information

Article type
Communication
Submitted
17 Feb 2010
Accepted
08 Jul 2010
First published
29 Jul 2010

Org. Biomol. Chem., 2010,8, 4255-4258

Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of α-aminophosphonic acid derivatives

F. Palacios, T. K. Olszewski and J. Vicario, Org. Biomol. Chem., 2010, 8, 4255 DOI: 10.1039/C003004J

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