Issue 8, 2010
From the journal:

Organic & Biomolecular Chemistry

Enantioselective assembly of the benzo[d]xanthene tetracyclic core of anti-influenza active natural products†‡

Duc Tran Ngoc,a   Martin Albicker,a   Lorenz Schneidera  and  Nicolai Cramer*a  

* Corresponding authors

a Laboratory of Organic Chemistry, ETH Zurich, HCI H 304, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
E-mail: nicolai.cramer@org.chem.ethz.ch
Fax: +41 44 632 1328
Tel: +41 44 632 6412

Abstract

A combination of an enantioselective conjugate addition/trapping sequence and a ruthenium(III)-catalyzed domino cyclization provides a concise access to benzo[d]xanthenes found in several anti-influenza active sesquiterpene natural products.

Graphical abstract: Enantioselective assembly of the benzo[d]xanthene tetracyclic core of anti-influenza active natural products

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Article information

DOI
https://doi.org/10.1039/C002011G
Article type
Communication
Submitted
01 Feb 2010
Accepted
02 Mar 2010
First published
11 Mar 2010

Org. Biomol. Chem., 2010,8, 1781-1784

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Enantioselective assembly of the benzo[d]xanthene tetracyclic core of anti-influenza active natural products

D. T. Ngoc, M. Albicker, L. Schneider and N. Cramer, Org. Biomol. Chem., 2010, 8, 1781 DOI: 10.1039/C002011G

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