Issue 5, 2010
From the journal:

Organic & Biomolecular Chemistry

Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids†

Tomonori Kawashima,a   Kei Ohkuboa  and  Shunichi Fukuzumi*ab  

* Corresponding authors

a Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency (JST), Yamada-oka 2-1, Suita, Osaka, Japan
E-mail: fukuzumi@chem.eng.osaka-u.ac.jp
Fax: (+81)-6-6879-7370
Tel: (+81)-6-6879-7368

b Department of Bioinspired Science, Ewha Womans University, Seoul, Korea

Abstract

UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.

Graphical abstract: Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids

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Article information

DOI
https://doi.org/10.1039/B924560J
Article type
Communication
Submitted
23 Nov 2009
Accepted
05 Jan 2010
First published
18 Jan 2010

Org. Biomol. Chem., 2010,8, 994-996

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Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids

T. Kawashima, K. Ohkubo and S. Fukuzumi, Org. Biomol. Chem., 2010, 8, 994 DOI: 10.1039/B924560J

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