Issue 5, 2010
From the journal:

Organic & Biomolecular Chemistry

Multicomponent asymmetric reactions mediated by proline lithium salt†

Polyssena Renzi,a   Jacob Overgaard‡a  and  Marco Bella*a  

* Corresponding authors

a Dipartimento di Chimica, Università” Sapienza” di Roma, and Istituto di Chimica Biomolecolare del CNR, P.le Aldo Moro 5, Roma, Italy
E-mail: marco.bella@uniroma1.it

Abstract

The multicomponent reaction between proline lithium salt, 2-cyclohexen-1-one and aliphatic aldehydes affords the 4-alkylidene-2-cyclohexen-1-ones, which are interesting fragrances, and bicyclic amino acids that bear four additional stereocenters, obtained as single stereoisomer.

Graphical abstract: Multicomponent asymmetric reactions mediated by proline lithium salt

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Article information

DOI
https://doi.org/10.1039/B924158B
Article type
Communication
Submitted
18 Nov 2009
Accepted
21 Dec 2009
First published
13 Jan 2010

Org. Biomol. Chem., 2010,8, 980-983

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Multicomponent asymmetric reactions mediated by proline lithium salt

P. Renzi, J. Overgaard and M. Bella, Org. Biomol. Chem., 2010, 8, 980 DOI: 10.1039/B924158B

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