Issue 7, 2010
From the journal:

Organic & Biomolecular Chemistry

A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection†

Baocun Zhu,a   Xiaoling Zhang,*a   Hongying Jia,b   Yamin Li,a   Haipeng Liuc  and  Weihong Tan*c  

* Corresponding authors

a Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, P. R. China
E-mail: Zhangxl@bit.edu.cn

b Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

c Center for Research at Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA
E-mail: tan@chem.ufl.edu

Abstract

A highly selective ratiometric fluorescent probe, which contains an aminonaphthalimide fluorophore and a self-immolative spacer for 1,4-dithiothreitol (DTT) detection was designed and synthesized. The probe displays a 66 nm red-shift of fluorescence emission and the color changes from colorless to jade-green upon reaction with DTT. These properties are mechanistically ascribed to the strong reducing capability of DTT.

Graphical abstract: A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection

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Article information

DOI
https://doi.org/10.1039/B923754B
Article type
Paper
Submitted
13 Nov 2009
Accepted
18 Jan 2010
First published
03 Feb 2010

Org. Biomol. Chem., 2010,8, 1650-1654

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A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection

B. Zhu, X. Zhang, H. Jia, Y. Li, H. Liu and W. Tan, Org. Biomol. Chem., 2010, 8, 1650 DOI: 10.1039/B923754B

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