Issue 3, 2010
From the journal:

Organic & Biomolecular Chemistry

Vinyl sulfone: a versatile function for simple bioconjugation and immobilization†

Julia Morales-Sanfrutos,a   Javier Lopez-Jaramillo,a   Mariano Ortega-Muñoz,a   Alicia Megia-Fernandez,a   Francisco Perez-Balderas,a   Fernando Hernandez-Mateoa  and  Francisco Santoyo-Gonzalez*a  

* Corresponding authors

a Departamento de Q. Orgánica, Facultad de Ciencia, Instituto de Biotecnologia, Universidad de Granada, Granada, 18071 SPAIN
E-mail: fsantoyo@ugr.es
Fax: (+34)-958243186
Tel: (+34)-958248087

Abstract

The easy functionalization of tags and solid supports with the vinyl sulfone function is a valuable tool in omic sciences that allows their coupling with the amine and thiol groups present in the proteogenic residues of proteins, in mild and green conditions compatible with their biological function.

Graphical abstract: Vinyl sulfone: a versatile function for simple bioconjugation and immobilization

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Article information

DOI
https://doi.org/10.1039/B920576D
Article type
Paper
Submitted
02 Oct 2009
Accepted
03 Nov 2009
First published
11 Dec 2009

Org. Biomol. Chem., 2010,8, 667-675

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Vinyl sulfone: a versatile function for simple bioconjugation and immobilization

J. Morales-Sanfrutos, J. Lopez-Jaramillo, M. Ortega-Muñoz, A. Megia-Fernandez, F. Perez-Balderas, F. Hernandez-Mateo and F. Santoyo-Gonzalez, Org. Biomol. Chem., 2010, 8, 667 DOI: 10.1039/B920576D

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