Issue 1, 2010

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

Abstract

A catalytic amount of TEMPO in the presence of PhI(OAc)2 effected oxidative lactonization of 1,6- and 1,7-diols, directly affording seven- and eight-membered lactones, respectively, in good yields.

Graphical abstract: Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

Supplementary files

Article information

Article type
Communication
Submitted
07 Jul 2009
Accepted
13 Oct 2009
First published
26 Oct 2009

Org. Biomol. Chem., 2010,8, 39-42

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

M. Ebine, Y. Suga, H. Fuwa and M. Sasaki, Org. Biomol. Chem., 2010, 8, 39 DOI: 10.1039/B919673K

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