Jump to main content
Jump to site search

Issue 4, 2010
Previous Article Next Article

Preparation, stability and cytocompatibility of magnetic/PLA-PEG hybrids

Author affiliations


Hybrid nanocolloids based on biodegradable polymers of poly(lactide) (PLA) or poly(lactide)-block-poly(ethylene glycol) (PLA-PEG) and hydrophobic iron oxide magnetic nanoparticles (MNPs) of ca. 5 nm are prepared via a self-assembly route. The magnetic nanoparticles are organized in superclusters inside the hydrophobic core of PLA-PEG micelles or cholate-stabilized PLA nanospheres. The hydrodynamic diameter of MNPs-loaded PLA nanospheres is ∼250 nm, whereas that of MNPs-loaded PLA-PEG micelles is much lower (∼100 nm) and thus compatible with applications where prolonged blood circulation is required. The PLA-PEG micelles exhibit high encapsulation efficiency for the MNPs, imparting a saturation magnetization value to the hybrid of 8.4 emu g−1. Both hybrid colloids display magnetic properties of a non-interacting assembly of superparamagnetic particles and a low blocking temperature, both of which are key attributes for colloidally stable ferrofluids. Furthermore, the PLA-PEG magnetic hybrids display remarkable colloidal stability at high ionic strength, temperature and in human blood plasma, while the estimated critical micelle concentration of ca. 2 × 10−5 mM (0.3 mg L−1) indicates the low probability of the colloids dissociation in the blood compartment. They were also found to be non-toxic to human cells in vitro. The results underline the potential of the magnetic/PLA-PEG hybrids and encourage further research for their in vivo biomedical applications.

Graphical abstract: Preparation, stability and cytocompatibility of magnetic/PLA-PEG hybrids

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Sep 2009, accepted on 20 Nov 2009 and first published on 25 Jan 2010

Article type: Paper
DOI: 10.1039/B9NR00253G
Citation: Nanoscale, 2010,2, 564-572
  •   Request permissions

    Preparation, stability and cytocompatibility of magnetic/PLA-PEG hybrids

    A. Bakandritsos, G. Mattheolabakis, R. Zboril, N. Bouropoulos, J. Tucek, D. G. Fatouros and K. Avgoustakis, Nanoscale, 2010, 2, 564
    DOI: 10.1039/B9NR00253G

Search articles by author