Issue 8, 2010
From the journal:

Natural Product Reports

Ciguatoxin: developing the methodology for total synthesis†

Minoru Isobe*a  and  Akinari Hamajimab  

* Corresponding authors

a Chemistry Department, National Tsing Hua University, Hsinchu, Taiwan

b Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba, Japan

Abstract

Covering: up to 2009

The ciguatoxins are sodium channel toxins from the marine dinoflagellate Gambierdiscus toxicus, isolated in 1984. In this review, we summarize the principal concepts and recently developed methodologies for the synthesis of the ciguatoxins, including C–C bond formation by silylacetylene and cobalt-mediated cyclization.

Graphical abstract: Ciguatoxin: developing the methodology for total synthesis

  • This article is part of the themed collection: Synthesis
About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B919467N
Article type
Review Article
Submitted
08 Apr 2010
First published
30 Jun 2010

Nat. Prod. Rep., 2010,27, 1204-1226

Permissions

Request permissions

Ciguatoxin: developing the methodology for total synthesis

M. Isobe and A. Hamajima, Nat. Prod. Rep., 2010, 27, 1204 DOI: 10.1039/B919467N

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements