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Issue 5, 2010
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Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

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Abstract

The cap structure was discovered at the 5′-end of the eukaryotic mRNA over three and a half decades ago. Since then, hundreds of chemically modified cap analogs have been synthesized and applied in numerous studies on the elucidation of cap-related physiological processes in the cell, and became important members of the biophosphate family. In this Perspective, we present recent developments in the synthesis of cap analogs modified within 5′,5′-triphosphate bridges and their utility for interdisciplinary studies on cap-dependent processes in gene expression and its regulation, as well as biotechnological applications and perspectives in medicine.

Graphical abstract: Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

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Article information


Submitted
19 Jan 2010
Accepted
05 Mar 2010
First published
08 Apr 2010

New J. Chem., 2010,34, 829-844
Article type
Perspective

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

J. Jemielity, J. Kowalska, A. M. Rydzik and E. Darzynkiewicz, New J. Chem., 2010, 34, 829
DOI: 10.1039/C0NJ00041H

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