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Issue 4, 2010
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Rapid assembly of potent type II dehydroquinase inhibitors via “Click” chemistry

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Abstract

The rapid synthesis of a library of potent type II dehydroquinase inhibitors is described. Inhibitors were prepared via a key quinate-derived ene-yne intermediate using Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) chemistry with a variety of aryl- and heteroaryl-azides.

Graphical abstract: Rapid assembly of potent type II dehydroquinase inhibitors via “Click” chemistry

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Publication details

The article was received on 02 Jul 2010, accepted on 20 Jul 2010 and first published on 23 Aug 2010


Article type: Concise Article
DOI: 10.1039/C0MD00097C
Med. Chem. Commun., 2010,1, 271-275

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    Rapid assembly of potent type II dehydroquinase inhibitors via “Click” chemistry

    A. T. Tran, K. M. Cergol, W. J. Britton, S. A. Imran Bokhari, M. Ibrahim, A. J. Lapthorn and R. J. Payne, Med. Chem. Commun., 2010, 1, 271
    DOI: 10.1039/C0MD00097C

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