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Issue 4, 2010
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Rapid assembly of potent type II dehydroquinase inhibitorsvia “Click” chemistry

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Abstract

The rapid synthesis of a library of potent type II dehydroquinase inhibitors is described. Inhibitors were prepared via a key quinate-derived ene-yne intermediate using Cu(I)-catalysed azide-alkynecycloaddition (CuAAC) chemistry with a variety of aryl- and heteroaryl-azides.

Graphical abstract: Rapid assembly of potent type II dehydroquinase inhibitorsvia “Click” chemistry

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Article information


Submitted
02 Jul 2010
Accepted
20 Jul 2010
First published
23 Aug 2010

Med. Chem. Commun., 2010,1, 271-275
Article type
Concise Article

Rapid assembly of potent type II dehydroquinase inhibitorsvia “Click” chemistry

A. T. Tran, K. M. Cergol, W. J. Britton, S. A. Imran Bokhari, M. Ibrahim, A. J. Lapthorn and R. J. Payne, Med. Chem. Commun., 2010, 1, 271
DOI: 10.1039/C0MD00097C

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