Issue 2, 2010
From the journal:

MedChemComm

Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates†

Shanshan Yan,a   Marvin J. Miller,*a   Timothy A. Wencewicza  and  Ute Möllmannb  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana, USA
E-mail: mmiller1@nd.edu
Fax: +1 574 631 6652
Tel: +1 574 631 7571

b Leibniz Institute for Natural Products Research and Infection Biology – Hans Knöell Institute, Beutenbergstrasse 11a, Jena, Germany

Abstract

Two cephalosporin-oxazolidinone conjugates were synthesized by incorporation of a carbamate linker at the 3′-position of the cephalosporin. These compounds show stability in aqueous media until specifically activated by a β-lactamase, and retain antibacterial activities profiles reflecting both the individual cephalosporin and oxazolidinone components.

Graphical abstract: Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates

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Article information

DOI
https://doi.org/10.1039/C0MD00015A
Article type
Concise Article
Submitted
18 Feb 2010
Accepted
31 Mar 2010
First published
05 May 2010

Med. Chem. Commun., 2010,1, 145-148

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Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates

S. Yan, M. J. Miller, T. A. Wencewicz and U. Möllmann, Med. Chem. Commun., 2010, 1, 145 DOI: 10.1039/C0MD00015A

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