Issue 3, 2010
From the journal:

MedChemComm

PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity†

Joana Matos,ab   Nuno Vale,ab   Margaret S. Collins,cd   Jiri Gut,e   Philip J. Rosenthal,e   Melanie T. Cushion,cd   Rui Moreiraf  and  Paula Gomes*ab  

* Corresponding authors

a Centro de Investigação em Química, Universidade do Porto, R. do Campo Alegre, 687, Porto, Portugal
E-mail: pgomes@fc.up.pt
Fax: +351 220402659
Tel: +351 220402563

b Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, R. do Campo Alegre, 687, Porto, Portugal
E-mail: pgomes@fc.up.pt
Fax: +351 220402659
Tel: +351 220402563

c Research Services, Veterans Affairs Medical Center, Cincinnati, OH, USA

d Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati, OH, USA

e Department of Medicine, San Francisco General Hospital, University of California, CA, USA

f iMed.UL, Faculdade de Farmácia, Universidade de Lisboa, Av. Professor Gama Pinto, Lisboa, Portugal

Abstract

Primacenes, novel ferrocene–primaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active against Pneumocystis carinii and devoid of cytotoxicity, thus being more selective than the parent drug.

Graphical abstract: PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity

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Article information

DOI
https://doi.org/10.1039/C0MD00082E
Article type
Concise Article
Submitted
17 Jun 2010
Accepted
21 Jun 2010
First published
08 Jul 2010

Med. Chem. Commun., 2010,1, 199-201

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PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity

J. Matos, N. Vale, M. S. Collins, J. Gut, P. J. Rosenthal, M. T. Cushion, R. Moreira and P. Gomes, Med. Chem. Commun., 2010, 1, 199 DOI: 10.1039/C0MD00082E

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