Issue 3, 2010
From the journal:

MedChemComm

Photo-degradation of amyloid β by a designed fullerene–sugar hybrid†

Yasunori Ishida,a   Shuho Tanimoto,a   Daisuke Takahashia  and  Kazunobu Toshima*a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Japan
E-mail: toshima@applc.keio.ac.jp
Fax: +81-45-566-1576
Tel: +81-45-566-1576

Abstract

A purpose-designed fullerene–sugar hybrid effectively inhibited amyloid β peptide aggregation and caused degradation of its monomer and oligomers, which are key compounds in Alzheimer's disease. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.

Graphical abstract: Photo-degradation of amyloid β by a designed fullerene–sugar hybrid

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Article information

DOI
https://doi.org/10.1039/C0MD00075B
Article type
Concise Article
Submitted
09 Jun 2010
Accepted
07 Jul 2010
First published
04 Aug 2010

Med. Chem. Commun., 2010,1, 212-215

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Photo-degradation of amyloid β by a designed fullerene–sugar hybrid

Y. Ishida, S. Tanimoto, D. Takahashi and K. Toshima, Med. Chem. Commun., 2010, 1, 212 DOI: 10.1039/C0MD00075B

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