Jump to main content
Jump to site search

Issue 1, 2010
Previous Article Next Article

Predicting proteinprotein interactions in the context of protein evolution

Author affiliations

Abstract

Here we review the methods for the prediction of protein interactions and the ideas in protein evolution that relate to them. The evolutionary assumptions implicit in many of the protein interaction prediction methods are elucidated. We draw attention to the caution needed in deploying certain evolutionary assumptions, in particular cross-organism transfer of interactions by sequence homology, and discuss the known issues in deriving interaction predictions from evidence of co-evolution. We also conject that there is evolutionary knowledge yet to be exploited in the prediction of interactions, in particular the heterogeneity of interactions, the increasing availability of interaction data from multiple species, and the models of protein interaction network growth.

Graphical abstract: Predicting protein–protein interactions in the context of protein evolution

Back to tab navigation

Publication details

The article was received on 18 Aug 2009, accepted on 28 Aug 2009 and first published on 28 Sep 2009


Article type: Review Article
DOI: 10.1039/B916371A
Citation: Mol. BioSyst., 2010,6, 55-64

  •   Request permissions

    Predicting proteinprotein interactions in the context of protein evolution

    A. C. F. Lewis, R. Saeed and C. M. Deane, Mol. BioSyst., 2010, 6, 55
    DOI: 10.1039/B916371A

Search articles by author

Spotlight

Advertisements