Issue 6, 2010
From the journal:

Molecular BioSystems

Preparation and characterization of lectin-conjugated chitosan fluorescent nanoparticles†

Jingping Liu,a   Lanlan Zhang,a   Chen Wang,b   Hongyan Xu*c  and  Xiaojun Zhao*ad  

* Corresponding authors

a Nanomedicine Laboratory, Center for Regenerative Medicine, West China Hospital, Sichuan University, Chengdu, P. R. China
E-mail: xiaojunz@mit.edu
Fax: +86-28-85164073
Tel: +86-28-85164069

b National Center of Nanoscience and Technology, Beijing 100080, P. R. China

c GL Biochem (Shanghai) Ltd., 519 Ziyue Rd., Shanghai 200241, P. R. China
E-mail: glsyn@mail.online.sh.cn
Web: http://www.glbiochem.com
Fax: +86-21-61263300
Tel: +86-21–61263333/61263398

d Center for Biomedical Engineering, NE47-379, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA

Abstract

The purpose of this study was to design and evaluate a novel target nanoparticle for disease detection and drug delivery using the biotin–avidin binding system. The formed lectin-conjugated chitosan fluorescent nanoparticles were of spherical shape (100–200 nm in diameter), which were more stable under light than pure fluorescein isothiocyanate (FITC).

Graphical abstract: Preparation and characterization of lectin-conjugated chitosan fluorescent nanoparticles

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Article information

DOI
https://doi.org/10.1039/B927040J
Article type
Communication
Submitted
23 Dec 2009
Accepted
26 Feb 2010
First published
08 Apr 2010

Mol. BioSyst., 2010,6, 954-957

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Preparation and characterization of lectin-conjugated chitosan fluorescent nanoparticles

J. Liu, L. Zhang, C. Wang, H. Xu and X. Zhao, Mol. BioSyst., 2010, 6, 954 DOI: 10.1039/B927040J

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