Jump to main content
Jump to site search

Issue 24, 2010
Previous Article Next Article

Overview of single-cell analyses: microdevices and applications

Author affiliations


Numerous microdevices developed for single-cell analyses have been presented in the last decades. Practical usefulness in biological and clinical settings has become an important focus during the development and implementation of new structures and assays. Single-cell analysis has been applied in intracellular research, gene- and protein content and expression, PCR, cell culture and division, clone formation, differentiation, morphology, lysis, separation, sorting, cytotoxicity and fluorescence screens, antibody secretion, etc. as discussed here along with brief descriptions of the technical devices used for the studies, e.g. well-, trap-, pattern-, and droplet-based structures. This review aims to serve as an overview of available techniques for single-cell analysis by describing the different biological single-cell assays that have been performed to date and how each individual application requires a particular device design.

Graphical abstract: Overview of single-cell analyses: microdevices and applications

Back to tab navigation

Article information

28 Jun 2010
14 Sep 2010
First published
22 Oct 2010

Lab Chip, 2010,10, 3363-3372
Article type
Critical Review

Overview of single-cell analyses: microdevices and applications

S. Lindström and H. Andersson-Svahn, Lab Chip, 2010, 10, 3363
DOI: 10.1039/C0LC00150C

Social activity

Search articles by author