Near-infrared absorbing and luminescent gold speckled silica nanoparticles for photothermal therapy

Parvesh Sharma; Scott C. Brown; Amit Singh; Nobutaka Iwakuma; Georgios Pyrgiotakis; Vijay Krishna; Jacquelyn A. Knapik; Keira Barr; Brij M. Moudgil; Stephen R. Grobmyer

doi:10.1039/C0JM00354A

Near-infrared absorbing and luminescent gold speckled silicananoparticles for photothermal therapy†

Parvesh Sharma,^a Scott C. Brown,^a Amit Singh,^a Nobutaka Iwakuma,^b Georgios Pyrgiotakis,^a Vijay Krishna,^a Jacquelyn A. Knapik,^c Keira Barr,^c Brij M. Moudgil*^a and Stephen R. Grobmyer*^b

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* Corresponding authors

^a Materials Science and Engineering & Particle Engineering Research Center, University of Florida, Gainesville, Florida, USA
E-mail: bmoudgil@perc.ufl.edu
Fax: +352 846 1196
Tel: +352 846 1194

^b Department of Surgery, University of Florida, Gainesville, Florida, USA
E-mail: Stephen.grobmyer@surgery.ufl.edu
Tel: +352 265 0169

^c Department of Pathology, University of Florida, Gainesville, Florida, USA

Abstract

Herein, we report the development and functional evaluation of sub-50 nm near-infrared absorbing and luminescent gold speckled silica (GSS) nanoparticles for fluorescence traceable and selective, in vitro and in vivo photothermal ablation applications. The nanoparticles prepared using microemulsion-mediated approach, are comprised of GRAS (generally regarded as safe) materials, and are promising multifunctional agents for image guided photo-mediated therapies.

Journal of Materials Chemistry

Near-infrared absorbing and luminescent gold speckled silicananoparticles for photothermal therapy†

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Near-infrared absorbing and luminescent gold speckled silica nanoparticles for photothermal therapy

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