Issue 40, 2010

Mussel-inspired functionalization of carbon nanotubes for hydroxyapatitemineralization

Abstract

Hydroxyapatite (HAp)/carbon nanotubes (CNTs) hybrid composite materials are successfully synthesized via a biomineralization process that employs poly(dopamine) (PDA), a synthetic mimic of mussel adhesive proteins. Creating bio-inorganic composites for regenerative medicine requires appropriate fillers to enhance their mechanical robustness; for example, natural bones are composed mainly of HAp supported by collagen fibers. In this regard, many efforts have been made to harness HAp as a bone substitute through its integration with reinforcing fibrous materials such as CNTs. We found that the formation of a PDA ad-layer on the surface of CNTs changed the hydrophobic CNTs to become bioactive. This enabled efficient interaction between the CNTs and mineral ions (e.g., Ca2+), which facilitated the mineralization of HAp. CNTs functionalized with PDA (CNT-PDA) highly accelerated the formation of HAp when incubated in a simulated body fluid and exhibited a minimal cytotoxic effect on bone osteoblast cells compared to pristine or carboxylated CNTs. Our results show the potential of CNT-PDA as a scaffold material for bone tissue regeneration and implantation.

Graphical abstract: Mussel-inspired functionalization of carbon nanotubes for hydroxyapatite mineralization

Supplementary files

Article information

Article type
Paper
Submitted
06 May 2010
Accepted
23 Jul 2010
First published
14 Sep 2010

J. Mater. Chem., 2010,20, 8848-8853

Mussel-inspired functionalization of carbon nanotubes for hydroxyapatite mineralization

M. Lee, S. H. Ku, J. Ryu and C. B. Park, J. Mater. Chem., 2010, 20, 8848 DOI: 10.1039/C0JM01339K

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