Issue 42, 2010
From the journal:

Journal of Materials Chemistry

Anticancer drug encapsulated in inorganic lattice can overcome drug resistance†‡

Soo-Jin Choi,a   Go Eun Choi,b   Jae-Min Oh,c   Yeon-Ji Oh,b   Myung-Chul Parkb  and  Jin-Ho Choy*b  

* Corresponding authors

a Department of Food Science and Technology, Seoul Women's University, Seoul, Korea
E-mail: sjchoi@swu.ac.kr
Fax: +82 2 970 5977
Tel: +82 2 970 5634

b Center for Intelligent NanoBio Materials, Division of Nano Science BK21, Department of Bioinspired Science and Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea
E-mail: jhchoy@ewha.ac.kr
Fax: + 82 2 3277 4340
Tel: +82 2 3277 4135

c Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Gangwondo, Korea
E-mail: jaemin.oh@yonsei.ac.kr
Fax: +82 33 760 2182
Tel: +82 33 760 2368

Abstract

A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries.

Graphical abstract: Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

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Article information

DOI
https://doi.org/10.1039/B925831K
Article type
Paper
Submitted
07 Dec 2009
Accepted
22 Mar 2010
First published
17 May 2010

J. Mater. Chem., 2010,20, 9463-9469

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Anticancer drug encapsulated in inorganic lattice can overcome drug resistance

S. Choi, G. E. Choi, J. Oh, Y. Oh, M. Park and J. Choy, J. Mater. Chem., 2010, 20, 9463 DOI: 10.1039/B925831K

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