Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins†
Abstract
Integrins are ubiquitous transmembrane mechanoreceptors that elicit changes in
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* Corresponding authors
a
Vascular Biology Program, Departments of Medicine, Pathology and Surgery, Harvard Medical School and Children's Hospital, Boston, USA
E-mail:
don.ingber@wyss.harvard.edu
Fax: 617-432-7828
Tel: 617-432-7044
b Department of Integrative Medical Sciences, NEOUCOM, Rootstown, USA
c Department of Bioengineering, Imperial College London, London, UK
d Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, USA
e School of Engineering and Applied Sciences, Harvard University, Cambridge, USA
Integrins are ubiquitous transmembrane mechanoreceptors that elicit changes in
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