Issue 12, 2010
From the journal:

Green Chemistry

Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones†

Natalia Zotova,a   Klaus Hellgardt,b   Geoffrey H. Kelsall,b   Alan S. Jessimanc  and  King Kuok (Mimi) Hii*a  

* Corresponding authors

a Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, UK
E-mail: mimi.hii@imperial.ac.uk
Fax: +44 (0)20 75491142

b Department of Chemical Engineering and Chemical Technology, Imperial College London, Exhibition Road, South Kensington, London, UK

c Pfizer Global Research and Development, Ramsgate Road, Sandwich, UK

Abstract

A safe, practical and selective process for the aerobic oxidation of alcohols to aldehydes and ketones has been developed using an Ru catalyst in a continuous flow reactor. Benzylic and allylic alcohols are oxidised selectively to their corresponding aldehydes and ketones, including substrates containing N- and S-heteroatoms. The rate of turnover is compatible with that previously reported using batch or microchannel reactors under optimised conditions. A preliminary kinetic model is derived that is supported by experimental observations. Last but not least, tandem oxidation–olefination may be achieved without the need to isolate the alcohol intermediate or to switch solvent.

Graphical abstract: Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones

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Article information

DOI
https://doi.org/10.1039/C0GC00493F
Article type
Paper
Submitted
27 Aug 2010
Accepted
05 Oct 2010
First published
21 Oct 2010

Green Chem., 2010,12, 2157-2163

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Catalysis in flow: the practical and selective aerobic oxidation of alcohols to aldehydes and ketones

N. Zotova, K. Hellgardt, G. H. Kelsall, A. S. Jessiman and K. K. (. Hii, Green Chem., 2010, 12, 2157 DOI: 10.1039/C0GC00493F

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