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Issue 11, 2010
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Environmentally benign, one-pot synthesis of pyrans by domino Knoevenagel/6π-electrocyclization in water and application to natural products

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Abstract

In water medium, environmentally benign, facile, and efficient synthesis of pyrans was achieved in good yields by the reactions of a variety of cyclic 1,3-dicarbonyls with several α,β-unsaturated aldehydes. The key strategy was a formal [3+3] cycloaddition by domino Knoevenagel/6π- electrocyclization. This methodology was applied to the synthesis of biologically interesting pyranocoumarin, pyranoquinolinone, and pyranonaphthoquinone derivatives along with selected natural and non-natural products.

Graphical abstract: Environmentally benign, one-pot synthesis of pyrans by domino Knoevenagel/6π-electrocyclization in water and application to natural products

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Publication details

The article was received on 26 Jun 2010, accepted on 26 Aug 2010 and first published on 22 Sep 2010


Article type: Paper
DOI: 10.1039/C0GC00265H
Green Chem., 2010,12, 2003-2011

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    Environmentally benign, one-pot synthesis of pyrans by domino Knoevenagel/6π-electrocyclization in water and application to natural products

    E. J. Jung, B. H. Park and Y. R. Lee, Green Chem., 2010, 12, 2003
    DOI: 10.1039/C0GC00265H

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