Issue 38, 2010
From the journal:

Dalton Transactions

Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties†

Fabien Accadbled,a   Bernard Tinant,b   Eric Hénon,a   Danièle Carrez,cd   Alain Croisycd  and  Sandrine Bouquillon*a  

* Corresponding authors

a Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, Université de Reims Champagne-Ardenne, BP 1039, Reims Cedex, France

b CSTR 1, Place Louis Pasteur, Louvain-la-Neuve, Belgique

c INSERM U759, Bâtiment 112, Centre Universitaire, Orsay, France

d Centre de Recherche de l′Institut Curie, Orsay, France

Abstract

Original palladium complexes involving (−)-ephedrine, (−)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray analysis. In parallel with the experimental work, HF-DFT(B3LYP/PCM) computations were performed to obtain additional structural information. Their antiproliferative properties have been evaluated and some complexes showed small activities especially towards HT29 human cancer cells.

Graphical abstract: Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0DT00328J
Article type
Paper
Submitted
19 Apr 2010
Accepted
12 Jul 2010
First published
17 Aug 2010

Dalton Trans., 2010,39, 8982-8993

Permissions

Request permissions

Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties

F. Accadbled, B. Tinant, E. Hénon, D. Carrez, A. Croisy and S. Bouquillon, Dalton Trans., 2010, 39, 8982 DOI: 10.1039/C0DT00328J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements