Issue 18, 2010
From the journal:

Dalton Transactions

Non-heme iron(ii/iii) complexes that model the reactivity of lipoxygenase with a redox switch†

Fusheng Mei,a   Chunping Ou,a   Guiling Wu,a   Li Cao,a   Fang Han,a   Xianggao Meng,a   Ji Li,a   Dongfeng Li*ab  and  Zhanru Liao*a  

* Corresponding authors

a Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P. R. China
E-mail: dfli@mail.ccnu.edu.cn, zrliao@mail.ccnu.edu.cn
Fax: 86 27 67867232
Tel: 86 27 6786 2900

b State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, P. R. China

Abstract

Three ferrous/ferric complexes of a N6 hexadentate ligand, N,N,N′,N′-tetrakis(2-benzimidazolyl-methyl)ortho-diamine-trans-cyclohexane (ctb), [FeII(ctb)](ClO4)2·EtOH (1), [FeIII(OEt)(Hctb)](ClO4)3·EtOH (2), and [FeIII(OMe)(Hctb)](ClO4)3·3MeOH·4.5H2O (3), were synthesized and characterized as models of lipoxygenase. The lipoxygenase activities of the complexes were checked and the results indicate that ferrous complex 1 is inactive while ferric alkoxide complexes 2 and 3 show catalytic activity via the hydrogen atom abstraction reaction mechanism.

Graphical abstract: Non-heme iron(ii/iii) complexes that model the reactivity of lipoxygenase with a redox switch

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Article information

DOI
https://doi.org/10.1039/B924298H
Article type
Communication
Submitted
18 Nov 2009
Accepted
19 Feb 2010
First published
19 Mar 2010

Dalton Trans., 2010,39, 4267-4269

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Non-heme iron(II/III) complexes that model the reactivity of lipoxygenase with a redox switch

F. Mei, C. Ou, G. Wu, L. Cao, F. Han, X. Meng, J. Li, D. Li and Z. Liao, Dalton Trans., 2010, 39, 4267 DOI: 10.1039/B924298H

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