Markedly different cytotoxicity of the two enantiomers of C2-symmetrical Ti(IV) phenolato complexes; mechanistic implications

Cesar M. Manna; Edit Y. Tshuva

doi:10.1039/B920786B

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Markedly different cytotoxicity of the two enantiomers of C₂-symmetrical Ti(iv) phenolato complexes; mechanistic implications†

Cesar M. Manna^a and Edit Y. Tshuva*^a

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* Corresponding authors

^a Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
E-mail: tshuva@chem.ch.huji.ac.il
Fax: 972 2 6584282
Tel: 972 2 6586084

Abstract

The two enantiomers of a member of the highly active C₂-symmetrical bis(isopropoxo) Ti(IV) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.

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Article information

DOI: https://doi.org/10.1039/B920786B
Article type: Communication
Submitted: 29 Jun 2009
Accepted: 16 Oct 2009
First published: 02 Nov 2009

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Dalton Trans., 2010,39, 1182-1184

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Markedly different cytotoxicity of the two enantiomers of C₂-symmetrical Ti(IV) phenolato complexes; mechanistic implications

C. M. Manna and E. Y. Tshuva, Dalton Trans., 2010, 39, 1182 DOI: 10.1039/B920786B

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Dalton Transactions