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Issue 2, 2010
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Amino sugars and their mimetics via 1,2-oxazines

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This tutorial review covers recent research from our laboratory towards the synthesis of amino sugars and related carbohydrate mimetics employing 1,2-oxazines as crucial intermediates. The synthesis of new dideoxyamino carbohydrate derivatives, C2-branched 4-amino sugars and their mimetics, as well as sialic acid analogues, has been developed during the last few years. The results demonstrate that alkoxyallenes are ideal and versatile components for the chain elongation of carbohydrate derivatives. Our routes starting from 3,6-dihydro-2H-1,2-oxazines are presented in conjunction with two related examples from the recent literature. Finally, we discuss possible future applications of the described compounds as anti-inflammatory agents.

Graphical abstract: Amino sugars and their mimetics via 1,2-oxazines

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The article was received on 21 Jul 2009 and first published on 16 Oct 2009

Article type: Tutorial Review
DOI: 10.1039/B914356D
Chem. Soc. Rev., 2010,39, 549-557

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    Amino sugars and their mimetics via 1,2-oxazines

    F. Pfrengle and H. Reissig, Chem. Soc. Rev., 2010, 39, 549
    DOI: 10.1039/B914356D

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