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Issue 5, 2010
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Microwave-assisted cycloaddition reactions

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Cycloaddition reactions belong to one of the most well-investigated and widely used reactions in synthetic organic chemistry for the construction of (hetero)cyclic compounds in a single-step operation. In this tutorial review, a select number of examples of some [3+2] cycloadditions, i.e. for 1,2,3-triazole formation, as well as of some [4+2] and [2+2] cycloadditions are reviewed, where it has been proven that the application of microwave irradiation has a profound influence on the outcome of the reaction.

Graphical abstract: Microwave-assisted cycloaddition reactions

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The article was received on 28 Jul 2009 and first published on 01 Dec 2009

Article type: Tutorial Review
DOI: 10.1039/B815717K
Citation: Chem. Soc. Rev., 2010,39, 1467-1477

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    Microwave-assisted cycloaddition reactions

    P. Appukkuttan, V. P. Mehta and E. V. Van der Eycken, Chem. Soc. Rev., 2010, 39, 1467
    DOI: 10.1039/B815717K

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