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Issue 38, 2010
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Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis—a comparison

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Abstract

This perspective presents and assesses the development and capabilities of tip-enhanced Raman scattering (TERS) since its discovery in 2000. So far, this technique has proven to be valuable for studies of a variety of inorganic, organic and biochemical specimens. Due to its ability to provide chemical and topographic characterization in a single experiment at a sub-100 nm resolution, TERS has gained importance in super-resolution structural analysis. In this contribution the focus is set on applications with relevance in the biology and medical fields. The potential and challenges of this near-field technique are discussed with respect to state-of-the-art microscopic and spectroscopic imaging methods. Furthermore, possible ways to surpass current boundaries and an outlook to future projects are presented.

Graphical abstract: Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis—a comparison

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Publication details

The article was received on 17 Feb 2010, accepted on 19 Jul 2010 and first published on 23 Aug 2010


Article type: Perspective
DOI: 10.1039/C003316B
Citation: Phys. Chem. Chem. Phys., 2010,12, 12040-12049
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    Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis—a comparison

    T. Deckert-Gaudig and V. Deckert, Phys. Chem. Chem. Phys., 2010, 12, 12040
    DOI: 10.1039/C003316B

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