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Issue 22, 2010
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Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

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Abstract

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo13C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized 15N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 ± 16 s) and in vivo (126 ± 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized 15N labeled choline in live animals.

Graphical abstract: Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

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Publication details

The article was received on 02 Feb 2010, accepted on 23 Apr 2010 and first published on 12 May 2010


Article type: Paper
DOI: 10.1039/C002309B
Phys. Chem. Chem. Phys., 2010,12, 5818-5823

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    Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

    C. Cudalbu, A. Comment, F. Kurdzesau, R. B. van Heeswijk, K. Uffmann, S. Jannin, V. Denisov, D. Kirik and R. Gruetter, Phys. Chem. Chem. Phys., 2010, 12, 5818
    DOI: 10.1039/C002309B

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