Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 35, 2010
Previous Article Next Article

Hyperpolarized 19F-MRI: parahydrogen-induced polarization and field variation enable 19F-MRI at low spin density

Author affiliations

Abstract

The use of parahydrogen-induced polarization (PHIP) for signal enhancement in nuclear magnetic resonance spectroscopy (NMR) is well established. Recently, this method has been adopted to increase the sensitivity of magnetic resonance imaging (MRI). The transfer of non-thermal spin hyperpolarization—from parahydrogen to a heteronucleus—provides better contrast, thus enabling new imaging agents. The unique advantage of 19F-MRI is that it provides non-invasive and background-free active marker signals in biomedical applications, such as monitoring drugs that contain 19F. In former NMR spectroscopic experiments, hyperpolarized 19F nuclei were efficiently generated by using low magnetic field (Earth's field) conditions. In order to apply the method to 19F-hyperpolarized MRI, we chose an exploratory target molecule, for which a successful transfer of PHIP had already been attested. The transfer of hyperpolarization to 19F was further optimized by adequate field manipulations below Earth's magnetic field. This technique, called field cycling, led to a signal enhancement of about 60. For the first time, hyperpolarized 19F-MR images were received. Despite the low spin density of the sample (0.045‰ of the 1H density in H2O), a sufficient signal-to-noise was obtained within a short acquisition time of 3.2 s.

Graphical abstract: Hyperpolarized 19F-MRI: parahydrogen-induced polarization and field variation enable 19F-MRI at low spin density

Back to tab navigation

Article information


Submitted
19 Jan 2010
Accepted
12 May 2010
First published
07 Jul 2010

Phys. Chem. Chem. Phys., 2010,12, 10309-10312
Article type
Paper

Hyperpolarized 19F-MRI: parahydrogen-induced polarization and field variation enable 19F-MRI at low spin density

U. Bommerich, T. Trantzschel, S. Mulla-Osman, G. Buntkowsky, J. Bargon and J. Bernarding, Phys. Chem. Chem. Phys., 2010, 12, 10309
DOI: 10.1039/C001265C

Social activity

Search articles by author

Spotlight

Advertisements