Issue 10, 2010

Effects of bidirectional regulation on noises in gene networks

Abstract

To investigate the effects of bidirectional regulation on the noise in protein concentration, a theoretical and simple three-gene network model is considered. The basic idea behind this model is from Paulsson’s proposition (J. Paulsson, Phys. Life Rev. 2005, 2, 157–175), where the synthesis and degradation of a mRNA species corresponding to a target protein are regulated directly and indirectly by a certain σ-factor, and a random increase in the concentration of the σ-factor should increase both the synthesis and degradation rates of the mRNA species (bidirectional regulation). Using the standard Ω-expansion technique (linear noise approximation) and Monte Carlo simulation, our main results show clearly that for the steady-state statistics the effects of the noise of the σ-factor on the stochastic fluctuation of the target protein could partially cancel out.

Graphical abstract: Effects of bidirectional regulation on noises in gene networks

Article information

Article type
Paper
Submitted
19 Jun 2009
Accepted
15 Dec 2009
First published
20 Jan 2010

Phys. Chem. Chem. Phys., 2010,12, 2418-2426

Effects of bidirectional regulation on noises in gene networks

X. Zheng and Y. Tao, Phys. Chem. Chem. Phys., 2010, 12, 2418 DOI: 10.1039/B912111K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements