Issue 8, 2010
From the journal:

CrystEngComm

Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin heptahydrate†

Francesca P. A. Fabbiani,*a   Demetrius C. Levendis,b   Gernot Buth,c   Werner F. Kuhs,a   Norman Shanklandd  and  Heidrun Sowaa  

* Corresponding authors

a Georg August Universität Göttingen, GZG, Abteilung Kristallographie, Göttingen, Germany
E-mail: ffabbia@gwdg.de
Fax: +49 551 399521
Tel: +49 551 393935

b Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits 2050, South Africa

c Karlsruhe Institute of Technology, Institut für Synchrotronstrahlung (ISS), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, Germany

d Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow, Scotland, UK

Abstract

High-pressure crystallisation of an aqueous solution of the GABA analogue gabapentin at 0.8 GPa resulted in the formation of a previously unknown heptahydrate form, whose structure has been determined by in situ single-crystal X-ray diffraction. The structure and water framework of this unusually highly hydrated small molecule are described in detail.

Graphical abstract: Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin heptahydrate

  • This article is part of the themed collection: New Talent
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Article information

DOI
https://doi.org/10.1039/B924573A
Article type
Paper
Submitted
23 Nov 2009
Accepted
06 Jan 2010
First published
27 Jan 2010

CrystEngComm, 2010,12, 2354-2360

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Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin heptahydrate

F. P. A. Fabbiani, D. C. Levendis, G. Buth, W. F. Kuhs, N. Shankland and H. Sowa, CrystEngComm, 2010, 12, 2354 DOI: 10.1039/B924573A

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