Issue 45, 2010
From the journal:

Chemical Communications

Drug encapsulation within self-assembled microglobules formed by thermoresponsive supramolecules†

José E. Betancourt,a   Chandramouleeswaran Subramani,b   José L. Serrano-Velez,c   Eduardo Rosa-Molinar,c   Vincent M. Rotellob  and  José M. Rivera*a  

* Corresponding authors

a Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, USA
E-mail: jmrivortz@mac.com

b Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, USA

c Department of Biology, University of Puerto Rico Río Piedras Campus, San Juan, USA

Abstract

An 8-(phenyl)-2′-deoxyguanosine derivative self-assembles in aqueous media into discrete hexadecamers that further self-assemble above 32 °C into microglobules that encapsulate the drug doxorubicin.

Graphical abstract: Drug encapsulation within self-assembled microglobules formed by thermoresponsive supramolecules

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Article information

DOI
https://doi.org/10.1039/C0CC04063K
Article type
Communication
Submitted
24 Sep 2010
Accepted
09 Oct 2010
First published
25 Oct 2010

Chem. Commun., 2010,46, 8537-8539

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Drug encapsulation within self-assembled microglobules formed by thermoresponsive supramolecules

J. E. Betancourt, C. Subramani, J. L. Serrano-Velez, E. Rosa-Molinar, V. M. Rotello and J. M. Rivera, Chem. Commun., 2010, 46, 8537 DOI: 10.1039/C0CC04063K

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